XXIX.—The estimation of saccharin
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چکیده
منابع مشابه
Toxicological Aspects of Saccharin
Saccharin is a widely used sweetener especially prescribed for the diabetics. But since its discovery, its use has been a matter of controversy due to its tumour promoting abilities in second generations of rats. As a result, saccharin was thought to be unfit for human consumption. Later on various studies focused on the possible mechanism of carcinogenic effects of saccharin on different anima...
متن کاملCarcinogenicity of saccharin.
Saccharin is carcinogenic for the urinary bladder in rats and mice, and most likely is carcinogenic in human beings. The neoplasms of the urinary bladder are malignant and invade and metastasize. Male rats are more susceptible to urinary bladder carcinogenesis than female rats. Rats exposed as fetuses develop neoplasms more readily than rats exposed as weanlings. The lesions in the urinary blad...
متن کاملSafety of saccharin
Saccharin has been the focus of controversy nearly since its initial synthesis in 1879 by Fahlberg and Remsen. Its primary use has been as a non-caloric synthetic sweetener, but it is also being used commercially for a variety of other purposes including as an antiseptic, preservative, nickelplating, antistatic agent, and numerous other uses. It is an inexpensive, extremely stable chemical that...
متن کاملPhotoisomerization of saccharin.
Most known applications of saccharin and saccharyl derivatives and their potential for new uses rely on the thermal and photochemical stability of the saccharyl system. Here, we show that saccharin undergoes structural rearrangement when subjected to a narrow-band ultraviolet irradiation. Monomeric saccharin was isolated in low-temperature argon matrices and its photochemistry was characterized...
متن کاملSynthesis of Novel Saccharin Derivatives.
The synthesis of saccharin (1,2-benzisothiazol-3-one-1,1-dioxide) derivatives substituted on the benzene ring has seen limited development despite the longevity of this compound's use as an artificial sweetener. This type of saccharin derivative would however present attractive properties for the development of new bioactive, drug-like small molecule compounds. Here we report the derivatisation...
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ژورنال
عنوان ژورنال: J. Chem. Soc., Trans.
سال: 1905
ISSN: 0368-1645
DOI: 10.1039/ct9058700242